September 27th, 2022

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Sperm Penetration Assay in Predicting Successful in Vitro Fertilization: A Meta-analysis
Authors:  Ben W. J. Mol, M.D., Saskia Meijer, M.D., Simone Yuppa, M.D., Erwin Tan, M.D., Jan de Vries, M.Sc., Patrick M. M. Bossuyt, Ph.D., and Fulco van der Veen, M.D., Ph.D.
  OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF).
METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF.

RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity.

CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF-
embryo transfer. (J Reprod Med 1998;43:503-508)
Keywords:  fertilization, in vitro; meta-analysis; sperm penetration; infertility, female
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