September 25th, 2023

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Association Between Serum Estradiol and Progesterone on the Same Day of Frozen Embryo Transfer and the Pregnancy Outcome
Authors:  Kamal Eldin Abdalla Rageh, M.D., Ahmed Abdul-Azim Barakat, FRCOG, Nada Ahmed Barakat, M.Sc., and Mohamed Atef Behery, M.D.
  OBJECTIVE: To investigate the impact of serum E2 and progesterone (P) levels on the same day of embryo transfer on pregnancy outcomes for frozen embryo transfer (FET) cycles.

STUDY DESIGN: This was a retrospective, cross-sectional study of 402 FET cycles conducted between April 2018 and May 2019. All participants started endometrial preparation for FET with 6 mg/day oral estradiol for 13 days. When the endometrium reached ≥8 mm, patients were initiated on both micronized vaginal and oral P treatment. On FET day, serum levels of E2 and P were assessed. Then, transfer of PGT euploid embryos was performed. Twelve days later a pregnancy test was given, and then 4 weeks after the FET date an ultrasound was scheduled to check the viability and the clinical pregnancy.

RESULTS: The mean E2 value was 931.41±438.65 pg/mL, while mean P value was 8.47±9.4 ng/mL. A total of 240 out of 402 cases achieved pregnancy (59.7%), while the clinical pregnancy rate was 53.9% with no correlation between serum (E2, P, and E/P ratio) and the outcome.

CONCLUSION: Our results revealed that the association between E2 and P on FET day and pregnancy outcome is still not proven and those markers cannot serve as predictors for the outcome.
Keywords:  assisted reproductive technologies, estradiol, frozen embryo transfer, progesterone
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