December 7th, 2021

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Title:
Genetic Counseling and Diagnosis of Dicephalus Parapagus Conjoined Twins with Umbilical Hernia During the First Trimester of Pregnancy: A Case Report
Authors:  Begzudin Ahmetovic, M.D., Ph.D., Milenko Kolarski, M.D., Ph.D., Jasmina Katanic, M.D., Ph.D., and Milos Pantelic, M.D., Ph.D.
 
BACKGROUND: Conjoined twinning is a rare congenital malformation with an incidence of 1:50,000 to 1:100,000.

CASE: We report the case of a woman with prenatal diagnosis of dicephalus parapagus conjoined twins at the 12th week of gestation. Ultrasound examination revealed monochorionic-monoamniotic twin pregnancy with conjoined twins sharing 2 parietally fused heads, 1 trunk, a single heart, 2 upper limbs, and 2 lower limbs. Early amniocentesis confirmed a normal female karyotype. The parents opted for termination of pregnancy, and the pathoanatomical examination of the fetus confirmed the diagnosis of dicephalic parapagus conjoined twins.

CONCLUSION: Accurate prenatal imaging is crucial in diagnosing this rare entity. Early prenatal diagnosis provides appropriate and timely prenatal counseling to the family.
Keywords:  amniocentesis; conjoined twins; diagnostic imaging; dicephalus parapagus; early diagnosis; magnetic resonance imaging; parapagus; pregnancy; teratology; twins, conjoined
   
   
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