August 2nd, 2021

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The Impact of the Ovarian Endometrioma on Baseline Serum Anti-Müllerian Hormone Level and Natural Conception Outcomes After Laparoscopic Treatment
Authors:  Zhou Yanzhen, M.M., Huang Xinxin, M.M., Shi Mengjing, M.B., and Chen Li, M.B.
  OBJECTIVE: To evaluate the impact of ovarian endometrioma on the serum anti-Müllerian hormone (AMH) level and natural postoperative conception outcomes in patients with endometriosis lesions.

STUDY DESIGN: A retrospective analysis was conducted of 164 women (≤35 years) with infertility: 92 patients with ovarian endometrioma (case group) and 72 patients with tubal infertility (control group). All patients underwent laparoscopic treatment. After the surgical procedure the patients were followed up over a period of 12–24 months to assess the frequency of natural pregnancy. Their basal serum AMH levels were compared.

RESULTS: The serum AMH level of patients with endometriosis was not significantly lower than that of the control group. However, the serum AMH level was significantly lower in patients with large ovarian endometrioma (≥5 cm) than in those with small ovarian endometrioma (<5 cm). The endometriosis fertility index (EFI) score was significantly correlated with pregnancy outcome (p=0.002). Patients with endometriosis reported a cumulative natural pregnancy rate of 53.48% during the 1–2 postoperative years.

CONCLUSION: Ovarian endometriomas (≥5 cm) independently affect the serum AMH level. The EFI score significantly correlates with postoperative pregnancy outcome, which indicates that surgical intervention can efficiently improve the fertility outcomes for patients with endometriosis.
Keywords:  anti-Mullerian hormone, endometriosis, endometriosis fertility index, infertility, laparoscopy, ovarian endometrioma, natural pregnancy outcome
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