August 2nd, 2021

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Current Status of Anticoagulant Therapy in Unexplained Recurrent Spontaneous Abortion
Authors:  Shuhai Lan, M.D., Shengwen Dong, Ph.D., and Shuwen Tang, M.D.
  Unexplained recurrent spontaneous abortion (URSA) is a difficult problem in obstetrics which often brings serious psychological and economic burden to patients and families, but there is still no effective prevention and treatment method. Some studies suggest that the occurrence of URSA is related to a prethrombotic state and placental vascular thrombosis. The decrease of placental blood perfusion leads to embryonic dysplasia or abortion. Anticoagulant therapy has always been considered by the obstetrics community, but the research opinions are not consistent. With regard to whether anticoagulant drugs such as low-molecular-weight heparin and aspirin can effectively improve pregnancy outcomes of unexplained recurrent spontaneous abortion, this paper collates the relevant data, summarizes the application status of anticoagulant therapy in patients with unexplained recurrent spontaneous abortion, and provides reference for clinical treatment.
Keywords:  abortion, habitual; abortion, spontaneous; antibodies, antiphospholipid; anticoagulant therapy; aspirin; low-molecular-weight heparin; placenta; placenta diseases; pregnancy; pregnancy outcome; thrombophilia; unexplained recurrent spontaneous abortion
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