June 14th, 2021

A full text version of this article is available.
To access article obtain online access here or login
No Associations Between Ureaplasma urealyticum, Chlamydia trachomatis, and HPV Infections and the Implantation Outcomes of IVF-ET in Women with Infertility
Authors:  Lin Liang, M.D., Shilei Hou, B.S., Xiujuan Chen, Ph.D., and Xiaoxi Zhao, Ph.D.
  OBJECTIVE: To analyze Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), and human papillomavirus (HPV) infections from the cervical secretions of patients undergoing in vitro fertilization–embryo transfer (IVF-ET) and their impact on the implantation outcomes of IVF-ET.

STUDY DESIGN: This was a retrospective study of 520 otherwise healthy women with infertility. UU, CT, and HPV statuses were tested routinely. IVF-ET was performed routinely. Data on hormone indicators of ovulation induction therapy, retrieved oocytes, mature oocytes, fertilization, good embryos, and embryo implantation rate were analyzed.

RESULTS: The comparison of infection status showed that the HPV infection groups had lower fertilization, cleavage, and embryo numbers, and the coinfections of UU+CT and UU+HPV had lower pregnancy and implantation rates. The multivariable analysis showed that age, body mass index, ovarian factors, and endometrium thickness on the day of transfer were independently associated with unsuccessful implantation in women undergoing IVF-ET. It was found that infection rates of UU (39.0%), CT (0.8%), HPV (4.0%), and combined infection rates with UU (UU+CT: 2.2%, UU+HPV: 8.9%, UU+CT+HPV: 0.8%) were significantly higher in the tubal factor groups. UU infection rates in infertility were also significantly different between the ovarian factors and sperm factor groups and between the endometrial factors and sperm factor groups.

CONCLUSION: Infection with UU, CT after treatment, and HPV has no significant impact on embryo implantation during IVF-ET. UU infection histories were associated with the
type of infertility.
Keywords:  assisted reproductive techniques, embryo implantation, Ureaplasma urealyticum, Chlamydia trachomatis, human papillomavirus, in vitro fertilization, implantation outcomes, infertility, mycoplasma infections, reproductive tract infections, sexually transmitted diseases, ureaplasma infections, ureaplasma urealyticum
  Acrobat Reader 7.0 is recommended to properly view and print the article.
Reader can be downloaded from