August 2nd, 2021

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Association Between Concentrations of Serum 25(OH)D and Outcomes of in Vitro Fertilization
Authors:  Ya Chen, M.S., Haiyan Yang, M.S., and Xuefeng Huang, Ph.D.
  OBJECTIVE: To investigate whether vitamin D deficiency impacts the outcomes of in vitro fertilization and explore whether serum 25(OH)D levels at baseline (groups A and B) or on the day of oocyte retrieval (groups C and D) could predict the pregnancy outcomes following in vitro fertilization (IVF).

STUDY DESIGN: According to 25(OH)D levels, the patients (n=307) were divided into 4 groups: Groups A and C, <50 nmol/L; and Groups B and D, ≥50 nmol/L. After treatment, clinical and laboratory indicators were analyzed.

RESULTS: No significant differences were found in body mass index, baseline follicle-stimulating hormone, peak estradiol (E2), oocyte numbers, fertilization rate, good-quality embryo rate, and rates of implantation and clinical pregnancy of fresh transfer cycles, but patients in group A were younger than those in group B. Compared with group D, oocyte numbers and rates of maturation and good-quality embryos in group C were significantly higher.

CONCLUSION: 25(OH)D levels were not associated with the clinical pregnancy outcomes following IVF.
Keywords:  25-hydroxyvitamin D, 25(OH)D, assisted reproductive techniques, in vitro fertilization, long protocol, pregnancy, vitamin D, vitamin D deficiency
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