August 2nd, 2021

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Effects of Different Categories of Female Chromosomal Polymorphisms on Outcomes of IVF-ET Cycles
Authors:  Xiaohui Zhang, M.S., Weihong Tan, M.B.B.S., Weiying Mo, M.B.B.S., Shikai Wang, M.S., Yaoxi Mo, M.M., and Lintao Xue, Ph.D.
  OBJECTIVE: To determine whether different categories of female chromosomal polymorphisms could affect the outcomes of in vitro fertilization–embryo transfer (IVF-ET).

STUDY DESIGN: We retrospectively analyzed data from 4,349 infertile couples and selected 168 with the following female karyotypes: 52 with qh+ (group 1), 31 with inv(9)(p12q13) (group 2), 85 with D/G genome variation (group 3), and 269 with normal karyotypes (control; group 4). We then compared the clinical outcomes of IVF and ET among the groups.

RESULTS: The most frequent chromosomal polymorphisms were 1qh+ (1.17%), inv(9)(p12q13) (1.03%), and 21pstk+ (0.87%). Embryo cleavage rates were significantly lower in groups 1 and 3 as compared with those in the control group (98.53% vs. 99.46%, p=0.037; 98.27% vs. 99.46%, p=0.002, respectively). Clinical pregnancy rates were significantly lower in group 1 as compared with those in the control group (33.33% vs. 51.00%, p=0.025). Binary logistic regression analysis showed that group 1 had lower rates of clinical pregnancy and live births than did the control group (odds ratio [OR]=0.432, p=0.016; OR=0.468, p=0.046, respectively).

CONCLUSION: Polymorphic variations in female qh+ and D/G adversely influence IVF-ET outcomes.
Keywords:  chromosomal polymorphism, cleavage, clinical outcome, embryo transfer, in vitro fertilization, pregnancy rate
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