August 2nd, 2021

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Prevalence of Mycoplasma/Ureaplasma Infections in Women Presenting with Recurrent Vaginitis in the Ambulatory Setting
Authors:  Esra Demirel, M.D., Stephanie Trentacoste McNally, M.D., Weiwei Shan, Ph.D., and Gary L. Goldberg, M.D.
  OBJECTIVE: To redefine recurrent vaginitis in the ambulatory setting and offer information to consider searching for additional vaginal microbes such as Mycoplasma/Ureaplasma that could cause persistent vaginitis symptoms.

STUDY DESIGN: This is a retrospective chart review of 3,849 office visits coded with an ICD-9 and ICD-10 code for vaginitis. Of the reviewed charts, 553 visits showed at least 1 episode of Mycoplasma and/or Ureaplasma infection. Incidence, demographics, concurrence with other infections, and recurrence rates were analyzed, where recurrence was defined as return to clinic for vaginitis symptoms >2 times a year or for 2 consecutive years.

RESULTS: The prevalence of Ureaplasma/Mycoplasma was 14% in this ambulatory site, and 73.4% of those women returned with recurrent symptoms. There were no significant differences in the rates of recurrent vaginitis for women based on ethnicity, race, or relationship status. The differences between contraceptive categories were significantly different where most of the recurrent infections occurred in women using hormonal contraceptive measures.

CONCLUSION: If a woman has persistent vaginitis symptoms and seeks care more than once a year or returns for continued symptoms in subsequent years, there may be additional pathogens that need to be addressed.
Keywords:  bacterial vaginosis, mycoplasma, ureaplasma, vaginal microbiome, vaginitis, vulvovaginitis
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