August 9th, 2022

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High-Dose Palliative Radiation Therapy for Solitary Recurrence of Ovarian Cancer in the Brain: A Case Report
Authors:  Alex Y. Chen, M.D., Ph.D., Jessica K. Sassic, B.S., Mazen Mislmani, M.D., and Anna V. Hoekstra, M.D., M.P.H.
BACKGROUND: Brain metastases from ovarian cancer are rare and are associated with a poor prognosis.

CASE: A 53-year-old woman presented with stage IIIC high-grade serous ovarian cancer. Nineteen months later, new neurologic symptoms led to a diagnosis of oligometastatic brain recurrence. She was treated with subtotal resection and declined adjuvant therapy, leading to a rapid regrowth of the tumor with a significant midline shift. She received urgent, aggressive partial brain radiotherapy. She has been without evidence of disease for 44 months since recurrence.

CONCLUSION: Aggressive multimodality therapy may be considered in patients with metastatic ovarian cancer to the brain.
Keywords:  brain metastases, ovarian cancer, palliative treatment, radiation therapy, surgery
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