August 9th, 2022

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Withdrawal of Luteal Phase Support in the Management of Ectopic Pregnancy Following Frozen Embryo Transfer: A Case Report
Authors:  Hannah M. Ware, M.D., Vinita M. Alexander, M.D., and Valerie S. Ratts, M.D.
BACKGROUND: Management of ectopic pregnancy includes expectant, medical, or surgical approaches. Assisted reproductive technology (ART) is a risk factor for ectopic pregnancy. Expectant management is less well studied in patients utilizing ART with frozen embryo transfer (FET).

CASE: After undergoing FET, a 50-year-old woman developed a tubal ectopic pregnancy. Hormonal support of the luteal phase was stopped. Serial β-hCG measurement and transvaginal ultrasounds documented resolution.

CONCLUSION: This is one of the first case reports describing withdrawal of hormonal support as successful management of ectopic pregnancy following FET. In selected cases, this management strategy may help patients avoid side effects of methotrexate and surgery and, in patients seeking conception via ART, may prevent delays until the next ART cycles.
Keywords:  abortifacient agents; abortion, spontaneous; assisted reproductive technology; chorionic gonadotropin; diagnosis, differential; embryo transfer; fertilization; luteal phase; methotrexate; pregnancy, ectopic; ultrasonography; watchful waiting
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