August 9th, 2022

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Cross-Sectional Association Between Hypertension and Asymptomatic Uterine Leiomyoma Detected During Routine Screening in Premenopausal Chinese Women
Authors:  Lin Meng, M.D., Na Liu, M.D., Dandan Wang, M.D., Ying Wang, M.D., and Anna Sanchez, M.D.
  OBJECTIVE: To assess the associations of asymptomatic uterine fibroids with a history of hypertension and current blood pressure.

STUDY DESIGN: Cross-sectional data were collected in 2010 from premenopausal women who receive annual health evaluations. The study included 542 women over 40 years of age with or without hypertension. Blood pressure measurements and ultrasound scans were conducted as part of the participants’ annual examination. Subjects also completed a lifestyle and health history questionnaire specifically for research purposes.

RESULTS: Fibroids were detected in 165 (30.4%) subjects. Hypertension was reported by 133 (24.5%) women. As compared to women with no hypertension history, a lower body mass index–adjusted odds of having a fibroid was found among hypertensive women with hypertension diagnosed within the prior 5 years (OR=0.51; 95% CI 0.28–0.93, p=0.027), a hyperten-sion diagnosed after age 45 (OR=0.47; 95% CI 0.26–0.84, p=0.011), and a current blood pressure of systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg (OR= 0.45; 95% CI 0.24–0.85, p= 0.013).

CONCLUSION: Hypertension history had an inverse association with presence of asymptomatic uterine fibroids. This effect was limited to women with shorter duration of disease, older age at hypertension diagnosis, and greater current blood pressure.
Keywords:  Asian continental ancestry group, blood pressure, hypertension, pelvic ultrasound, uterine fibroids, uterine leiomyoma
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