August 2nd, 2021

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Comparing the Clinical Outcomes of Different Stage Embryos in Frozen Embryo Transfer in Patients with Recurrent Implantation Failure
Authors:  Li-hua Yang, M.D., Ke-da Yu, M.D., Rong Wang, M.D., Fang Wang, M.D., Hong Liu, M.D., and Li-bo Zou, M.D.
  OBJECTIVE: To compare the clinical outcomes of cleav­age stage embryo and blastocyst transfer in patients with recurrent implantation failure.

STUDY DESIGN: Medical records of patients who un­derwent 2 or more failed attempts of frozen­thawed embryo transfer at cleavage stage and still had frozen cleavage stage embryos were reviewed. Patients were di­vided into 2 groups. In group A (blastocyst stage, n=132), blastocysts were cultured to D5 or D6 after freeze­ thawing of cleavage stage embryos. In group B (cleavage stage embryo, n=164), D3 cleavage embryo resuscita­tion was observed. The number of embryos transferred, clinical pregnancy, implantation, multiple pregnancy, miscarriage, ectopic pregnancy, and live birth rate were compared.

RESULTS: Blastocyst formation rate of cleavage stage embryo after thawing was 55.27%. Cancellation rate in group A was 6.06%, while no cases of cancellation were seen in group B. Data showed a higher pregnancy rate in group A with 46.77% vs. 36.59% in group B. The implantation rate in group A was higher than that in group B (p<0.05). There were no differences in multi­ple pregnancy, miscarriage, ectopic pregnancy, and live birth rate between the 2 groups (p>0.05).

CONCLUSION: The blasto­ cyst transfer can achieve bet­ter clinical results, but it does have the risk of cancel­lation if there is no blastocyst formation.
Keywords:  assisted reproductive techniques; blastocyst culture techniques; cleavage stage, ovum; embryo culture techniques; embryo transfer; frozen-thawed embryo transfer; invitro fertilization; recurrent implantation failure
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