August 2nd, 2021

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Risk Factors for Depressed Mood and Anhedonia in Mothers of Infants with Twin-Twin Transfusion Syndrome
Authors:  Ellen McMahon, M.D., Lisa M. Korst, M.D., Ph.D., Hindi E. Stohl, M.D., J.D., Ramen H. Chmait, M.D., and Douglas L. Vanderbilt, M.D., M.S.
  OBJECTIVE: High-risk pregnancies pose risks to maternal mental health, but little is known regarding maternal mental health risks for pregnancies with twin-twin transfusion syndrome (TTTS). Our objective was to identify predictors of postpartum depressed mood and anhedonia in women who underwent laser surgery for TTTS.

STUDY DESIGN: Women treated for TTTS were surveyed for depressed mood and anhedonia at 3 months postpartum. Independent multiple logistic regression models were examined to identify predictors.

RESULTS: A total of 81 women responded (response rate, 40.1%); nearly half (45.7%) of the respondents reported postpartum depressed mood, 39.2% reported anhedonia, and 30.4% reported both. In the model for depressed mood, significant risk factors included the following: graduate school (OR 23.72, 95% CI 2.90– 193.86), p<0.01; unmarried (OR 17.19, 95% CI 2.18– 135.80), p<0.01; and depressed mood at time of treatment (OR 5.57, 95% CI 1.31–23.68), p=0.02. In the model for anhedonia, significant risk factors included anhedonia at time of treatment (OR 14.52, 95% CI 3.55–59.46), p<0.001; graduate school (OR 12.17, 95% CI 1.76–84.14), p=0.01; and unmarried (OR 8.79, 95% CI 1.21–63.88), p=0.03.

CONCLUSION: Among women with TTTS pregnancies treated with laser surgery, depressed mood and anhedonia were prevalent at 3 months postpartum. Prominent risk factors included being unmarried and having attended graduate school.
Keywords:  anhedonia, anxiety, depression, fetofetal transfusion syndrome, postpartum depression, pregnancy, risk factors, stress disorders, twin pregnancy, twin-twin transfusion syndrome, twins
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