September 25th, 2023

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Choriocarcinoma in Situ in a Partial Hydatidiform Mole: A Case Report
Authors:  Tha´s Baert, M.D., Joris Vermeesch, Ph.D., Dirk Timmerman, M.D., Ph.D., Ignace Vergote, M.D., Ph.D., and Philippe Moerman, M.D., Ph.D.
BACKGROUND: Choriocarcinoma most frequently arises in a complete hydatidiform mole. Less common are cases following a normal pregnancy or a non molar abortion. Its occurrence after a partial hydatidiform mole is extremely rare. CASE REPORT: Here we report a choriocarcinoma in situ diagnosed after dilation and curettage for a first trimester partial hydatidiform mole. The diagnosis was confirmed by immunohistochemistry, fluorescent in situ hybridization, and microsatellite instability genotyping of the products of conception and blood of the mother and father. We demonstrated a diandric triploidy. At the time of diagnosis CT scan showed lung metastasis. The patient was classified as high-risk gestational trophoblastic neoplasia and treated with high-dose methotrexateetoposide.

CONCLUSION: This is the first reported case of a choriocarcinoma arising in a first trimester partial mole.
Keywords:  choriocarcinoma; diandric triploidy; gestational trophoblastic neoplasia; hydatiform mole, partial; pregnancy, first trimester; pregnancy complications; triploidy
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