June 30th, 2022

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Short Interpregnancy Interval and Misoprostol as Additive Risks for Uterine Rupture: A Case Report
Authors:  C. E. Henderson, M.D., C.D.E., R. G. Hana, M.D., R. Woroch, M.D., and K. D. Reilly, M.D.
BACKGROUND: Short interpregnancy interval and uterine instrumentation are risk factors for uterine rupture in subsequent pregnancies. Misoprostol as a uterotonic agent is an additive risk factor for rupture of a scarred uterus.

CASE: Misoprostol induction for a term stillbirth was complicated by uterine rupture. Risk factors for this uterine rupture might have included interpregnancy intervals of <7 months, prior uterine instrumentation, and misoprostol as a uterotonic agent.

CONCLUSION: Caution and a high index of suspicion are warranted when using misoprostol as a uterotonic agent after a short interpregnancy interval.
Keywords:  interpregnancy interval, misoprostol, uterine rupture
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