June 30th, 2022

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Title:
Effect of Patient Age on Outcomes and Compliance in Women with Minimally Abnormal Pap Tests
Authors:  J. S. Carter, M.D., Y. Hoffman Sage, M.D., M.P.H., O. Vragovic, M.B.A., L. Rosen, M.S.E.E., and E. A. Stier, M.D.
  OBJECTIVE: To assess follow-up and histologic outcomes by age for an indigent urban cohort of women with minimally abnormal cytology.

STUDY DESIGN: Retrospective analysis of Pap tests was performed (January 2, 2002, to June 30, 2005). Adolescents (age <21) and women with atypical squamous cells of undetermined significance (ASCUS)/high-risk human papillomavirus (HPV) and low-grade squamous intraepithelial lesions (LSIL) Pap results were studied and followed for outcomes at 2 years. The c2 test was performed to evaluate differences among groups; statistical significance was established as p?0.05.

RESULTS: A total of 2,266 women were studied—676 adolescents, 1,063 women aged 21–30 years, and 527 women >30 years of age. Results included 619 ASCUS/ high-risk HPV and 1,647 LSIL results. Compliance was similar across age-groups; 31% never returned for
follow-up. CIN2 was detected in 18.8% of adolescents, 21.6% of women aged 21–30, and 15.7% of women >30 years (p=0.53). CIN3 was detected in 8.5% of adolescents, 8.1% of women aged 21–30, and 7.7% of women >30 years (p=0.55).

CONCLUSION: Adolescents and women had similar rates of loss to follow-up after having a minimally abnormal Pap test. The likelihood of detecting CIN2-3 was similar regardless of age.
Keywords:  atypical squamous cells of undeter- mined significance, cervical intraepithelial neoplasia, colposcopy, compliance, human papilloma virus, low-grade squamous intraepithelial lesion
   
   
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