June 30th, 2022

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Carcinoembryonic Antigen in Women with Isolated Pelvic Masses: Clinical Utility?
Authors:  Lynda D. Roman, M.D., Laila I. Muderspach, M.D., Alexander F. Burnett, M.D., and C. Paul Morrow, M.D.
  OBJECTIVE: To determine the usefulness of serum carcinoembryonic
antigen (CEA) determination in predicting
the nature of an isolated
pelvic mass.

hundred twenty-six women
with an isolated pelvic mass
had a serum CEA determination
preoperatively. The results
were correlated with the histopathologic findings.

RESULTS: CEA was elevated in 19 of the 226 women.
Twelve of the 183 (7%) women with benign masses, 2 of
the 17 (12%) women with tumors of low malignant potential
and 5 of the 15 (33%) women with a frankly invasive
epithelial ovarian cancer had elevated CEA. None
of the women with a malignant germ cell or stromal
tumor had elevated CEA (P=.06 for prediction of malignancy).
There were no cases of metastatic gastrointestinal
malignancies in the study group. The sensitivity,
specificity, positive predictive value and negative predictive
value of serum CEA were 16%, 93%, 37% and 83%,
respectively. The corresponding figures for serum CA-
125 were 67%, 71%, 35%
and 90%. There was no statistically
significant correlation
between elevated CEA
and mucinous histology.

CONCLUSION: Preoperative
serum CEA determination
in women with isolated pelvic masses is not useful.
(J Reprod Med 1998;43:403-407)
Keywords:  carcinoembryonic antigen, pelvic neoplasms, CA-125 antigen
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