May 29th, 2022

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A Rare Malignant Brenner Tumor of the Ovary in a 77-Year-Old Woman: A Case Report
Authors:  Karen S. Ballard, D.O., Brian C. Thurston, M.D., Michael D. Sennett, M.D., and Sean S. Tedjarati, M.D., M.P.H.
BACKGROUND: A malignant Brenner tumor is a rare form of invasive epithelial ovarian cancer and is extremely uncommon in women >65 years of age. We present a case of an invasive Brenner tumor of the ovary in a woman greater than age 70.

CASE: A 77-year-old woman presented with a rare, invasive Brenner tumor of the ovary. She was referred for evaluation of a complex pelvic mass and elevated serum CA-125. Treatment included complete surgical resection and staging procedure. Pathology revealed a malignant Brenner tumor. Immunohistochemical staining with cytokeratin 7 was positive, with cytokeratin 20 was negative, and was positive for uroplakin III and thrombomodulin.

CONCLUSION: The histologic appearance of malignant Brenner tumor is similar to that of transitional cell cancer of the ovary and transitional epithelium of the urinary bladder. Immunohistochemical staining of malignant Brenner tumor often demonstrates positivity for uroplakin III, thrombomodulin and cytokeratin 7 and negativity to cytokeratin 20. The mainstay of treatment is surgical resection, but the exact regimen and benefit of adjuvant therapy remain unknown. (J Reprod Med 2009;54:517-519)
Keywords:  malignant Brenner tumor, ovarian cancer, transitional cell
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