June 30th, 2022

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Recombinant Factor VIIa to Treat Late Radiation-Induced Hemorrhagic Cystitis: A Case Report
Authors:  John P. Geisler, M.D., Georgiann C. Linnemeier, M.D., and Kelly J. Manahan, M.D.
BACKGROUND: Late radiation cystitis is one of the most difficult complications of radiation therapy for pelvic malignancies.

CASE: A 29-year-old woman with a history of cervical cancer presented with
radiation-induced hemorrhagic cystitis. The patient received multiple units of packed red blood cells while undergoing several intravesical treatments, including continuous bladder irrigation, 4% formalin, 0.15% AgNO3 and Mg(OH)2 with Al(OH)3. The bleeding finally was stopped by the use of intravenous recombinant factor VIIa.

CONCLUSION: When hemorrhagic cystitis related to late radiation complications is refractory to conventional management, intravenous recombinant factor VIIa may be of benefit. (J Reprod Med 2008;53:360-362)
Keywords:  cervical cancer, hemorrhagic cystitis, hyperbaric oxygen, radiation complications
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