June 16th, 2019

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Title:
Antenatal Corticosteroids Increase the Risk of Hyperglycemia in Nonobese and Obese Nondiabetic Women
Authors:  Tara A. Lynch, M.D., Johanna C. Bringley, D.O., Erin C. Crosby, M.D., Kevin C. Kiley, M.D., and Asha Rijhsinghani, M.D.
  OBJECTIVE: The administration of antenatal cortico­ steroids is widely used in obstetrics for women at risk for preterm delivery. A commonly recognized side effect is maternal hyperglycemia. The impact of obesity on the level of hyperglycemia after corticosteroid administration in nondiabetic women is unknown.

STUDY DESIGN: A retro­spective study evaluating the relationship between obesity class and rates of hyperglycemia in nondiabetic women after the administration of antenatal corticosteroids. All nondiabetic women ad­ mitted to a single academic institution from January 2013–July 2015 who were monitored for hyperglycemia with blood glucose levels following corticosteroid admin­istration were included. The main outcome measure was rate of hyperglycemia stratified based on body mass index.

RESULTS: All women had elevated glucose levels after the administration of antenatal corticosteroids. Specifi­cally, 74.5% of patients had an initial glucose level ≥110 mg/dL and 94.1% had a maximum glucose ≥110 mg/dL. Nonobese patients had higher mean maximum glucose than did obese women.

CONCLUSION: As both nonobese and obese women have high rates of post­corticosteroid hyperglycemia, there may be a role for the monitoring of blood glucose levels in nondiabetic women, regardless of body mass index.
Keywords:  antenatal corticosteroids, betamethasone, diabetes mellitus, gestational diabetes, hyperglycemia, neonatal hypoglycemia, obesity, pregnancy, preterm birth, risk
   
   
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