July 10th, 2020

A full text version of this article is available.
To access article obtain online access here or login
Heavy Smoking Responsible for the Reduction of Antral Follicles and Lower Recovery of Oocytes in Assisted Reproduction Cycles: A Case Report
Authors:  Ana Karina Bartmann, M.D., Ph.D., Victor César de Paula S. Nascimento, B.Sc., Pérola Rafaella Cedano Godoy P. de Souza, M.D., and Heloisa Gomes, M.D.
BACKGROUND: As is widely known, smoking negatively influences fertility. Two mechanisms are accountable for this effect: oxidative stress and DNA damage, which lead to the toxicity of the substances present in tobacco.

CASE: A 38-year-old woman presented to the clinic for primary infertility. She had regular periods and had not used any contraceptive method for 10 years. She presented antral follicle counts of 5 and 9 in each treatment attempt but just 1 and 3 oocytes, respectively, due to age or high tobacco load. Both in vitro fertilization attempts were unsuccessful.

CONCLUSION: This case shows the great negative influence that tobacco has on fertility. It demonstrates the difficulty in attaining pregnancy in a treatment-compliant patient.
Keywords:  assisted reproductive technologies, cigarette smoking, in vitro fertilization, infertility, smoking, tobacco smoking
  Acrobat Reader 7.0 is recommended to properly view and print the article.
Reader can be downloaded from