July 10th, 2020

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Classical Symptoms and Risks Associated with an Ongoing Molar Pregnancy in Case of a Coexisting Twin
Authors:  Jan S. Erkamp, M.D., Marianne J. Ten Kate-Booij, M.D., Ph.D., Patricia Ewing-Graham, FRCPath, and Sam Schoenmakers, M.D., Ph.D.
  An uncommon presentation of molar pregnancy is a twin gestation with a normally developed fetus alongside a complete hydatidiform mole. Since the pregnancy of the normally developed fetus can progress to a viable term, continuation of a complete hydatidiform mole (CHM) can be allowed, whereby severe maternal molar-associated complications could develop. In this article we describe the pathophysiology and potential severe maternal mole-related morbidity associated with an ongoing molar pregnancy. Understanding the possibil-ity of reaching a viable term of the healthy co-twin, and being aware of the risks of continuing a CHM pregnancy, is an essential part of informed and shared decision-making.
Keywords:  complete hydatidiform mole, gestational trophoblastic disease, hydatidiform mole, molar pregnancy, twin
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