February 15th, 2019

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Lower Pregnancy Rates After IVF in Women Working as Occupational Cleaners: A Preliminary Longitudinal Study
Authors:  Sabrina Soen, M.D., Jeanne Perrin, M.D., Ph.D., Irène Sari-Minodier, M.D., Ph.D., Elisabeth Jouve, M.D., Ph.D., Audrey Gnisci, M.D., and Blandine Courbiere, M.D., Ph.D.
  OBJECTIVE: To assess clinical, biological, and environmental factors influencing pregnancy rates (PRs) after in vitro fertilization (IVF), and to study the influence of occupational, lifestyle, and domestic exposure on PR.

STUDY DESIGN: A longitudinal cohort study was performed in women who started an IVF cycle with a self-administered questionnaire concerning their environmental and occupational exposure. Medical data were obtained from medical files.

RESULTS: Among 534 cycles, we showed a variety of factors that had an impact on PR: age, infertility duration, number of mature oocytes and embryos. After multivariate analysis, women with “elementary” occupations had a significantly lower PR (OR 5.6; 95% CI 1.3–23.7). Among them, 82% were cleaners.

CONCLUSION: This preliminary result leads us to focus on a socio-professional category that is already recognized in the literature as at risk for congenital abnormalities during pregnancy. Further cohort studies are needed to study the influence of socio-professional category on PR.
Keywords:  assisted reproductive technologies, infertility, in vitro fertilization, IVF, pregnancy rate, occupational exposure
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