August 20th, 2018

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Relationship Between Endometrial Thickness and Pregnancy Outcome in Normal Responder Undergoing in Vitro Fertilization and with Transfer of Two Cleavage-Stage Embryos
Authors:  Ya Chen, M.D., Chun Zhou, Ph.D., Ling Ma, Ph.D., Su-qing Wang, Ph.D., and Zhi-dan Hong, M.D.
  OBJECTIVE: To evaluate the relationship between endometrial thickness and pregnancy outcome in patients with normal ovarian reserve undergoing in vitro fertilization–embryo transfer (IVF-ET) with 2 cleavage-stage fresh embryos transferred.

STUDY DESIGN: A retrospective cohort study including 2,986 patients who had their first IVF-ET from January 2009 to December 2014 was carried out at Zhongnan Hospital, Wuhan University. According to endometrial thickness measured on the day of human chorionic gonadotropin (hCG) administration, patients were divided into 3 groups: <7 mm (group A), 7–14 mm (group B), and >14 mm (group C). Treatment outcome in the different groups was analyzed.

RESULTS: The implantation, clinical pregnancy, and live birth rates were lowest in group A (p<0.05), but there was no significant difference among groups B and C. Multiple logistic regression analysis showed that age, top-quality embryos, and endometrial thickness on the day of hCG administration all contributed significantly to clinical pregnancy.

CONCLUSION: The implantation, clinical pregnancy, and live birth rates decreased when endometrial thick-ness was <7 mm, but endometrial thickness is not a
good predictor of clinical pregnancy and cannot establish a true cutoff value below which pregnancy would not occur.
Keywords:  cleavage-stage embryo, clinical pregnancy, embryo transfer, endometrial thickness, in vitro fertilization
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