October 17th, 2017

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Title:
Gestational Trophoblastic Disease: Experience at a Specialized National Maternity Hospital in El Salvador, “Dr. Raul Arguello Escolan,” January 2003–December 2012
Authors:  Roberto German Tobar Ponce, M.D., MPH, MHA
  OBJECTIVE: To describe the demography and clinical features of gestational trophoblastic disease (GTD) in a tertiary referral hospital in El Salvador.

STUDY DESIGN: Follow-up of a cohort of patients. The study was conducted using data retrieved from medical records from 2003–2012, assessing demographics, clinical features, and outcomes.

RESULTS: A total of 896 patients were identified, with a hospital average prevalence of 6.7 per 1,000 pregnancies. Complete hydatidiform mole (CHM) was the most frequent histological finding, at 88.5%. The mean age of the patients was 24.19 years, it was the first pregnancy in 62.9%, and they were diagnosed at 14 weeks’ gestation on average. Clinically, 9 patients (1%) presented with thyrotoxicosis. Most (98.9%) were diagnosed by transvaginal ultrasound and determination of serum human chorionic gonadotropin (β-hCG) levels. All (100%) underwent curettage, 55 (6.1%) needed hysterectomy, and 85.6% of patients did not receive chemotherapy. One patient with CHM died.

CONCLUSION: GTD in our series presented at a high prevalence as compared to reports in the literature. The most common type of presentation is CHM.
Keywords:  gestational trophoblastic disease; gestational trophoblastic neoplasia; hydatidiform mole; hydatidiform mole, complete; hydatidiform mole, partial; molar pregnancy
   
   
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