March 23rd, 2018

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Comparison of a 20-Second Wait to Immediate Withdrawal of the Catheter Following Ultrasound-Guided Blastocyst Transfer
Authors:  Ayse Arvas Ulug, M.D., Ph.D., Meric Karacan, M.D., Murat Ulug, Ph.D., Ziya Cebi, M.D., and Teksen Camlibel, M.D., Ph.D.
  OBJECTIVE: To compare the outcomes of in vitro fertilization cycles with a 20-second wait versus immediate withdrawal of the embryo transfer catheter after placement of blastocysts.

STUDY DESIGN: A total of 226 patients undergoing blastocyst transfer were prospectively randomized into 2 groups. Embryo transfer catheter was withdrawn immediately in 141 patients (Group I), and after a 20-second wait in 136 (Group II). Controlled ovarian hyperstimulation was performed using GnRH antagonist protocol, and a maximum of 2 blastocysts were transferred into midcavity.

RESULTS: Demographic and cycle characteristics as well as the number of blastocysts transferred were similar between the 2 groups. Implantation (25.8% vs. 25.7%), clinical pregnancy (38.2% vs. 38.9%), multiple pregnancy (18.5% vs. 16.7%), and miscarriage rates (9.7% vs. 9.8%) did not differ significantly between Groups I and II, respectively.

CONCLUSION: A 20-second delay of the embryo transfer catheter in the uterine cavity following blastocyst transfer does not result in a better outcome than immediate withdrawal. The advantage of prolonged time of retention of the catheter does not seem to exist between the 2 different waiting times used in this study.
Keywords:  assisted reproductive techniques, blastocyst transfer, embryo transfer, in vitro fertilization
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