March 23rd, 2018

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Association of Genetic Heterogeneity of PECAM1 and P-Selectin Genes with Implantation Failure After in Vitro Fertilization
Authors:  Nikolaos Vlachadis, M.D., D.M.D., M.P.H., M.Sc., D.Sc., Vasileios Tsamadias, B.Sc., Nikolaos Vrachnis, M.D., Ph.D., Konstantinos Hatziveis, M.D., Ph.D., Evaggelia Kouskouni, M.D., Ph.D., and Emmanuel Economou, Pharm.D., Ph.D.
  OBJECTIVE: To examine, for the first time in the literature, the contribution of PECAM1 and P-selectin polymorphisms in implantation failure after in vitro fertilization (IVF) embryo transfer.

STUDY DESIGN: PECAM1-C373G (Leu125Val) and P-selectin-A37674C (Thr715Pro) polymorphisms were investigated in 60 women with a history of IVF implantation failure and 60 fertile controls of Greek origin.

RESULTS: An increased risk of implantation failure was found for women who were carriers of the PECAM1-G allele, as compared with those who were PECAM1-C homozygotes (OR=2.79, 95% CI 1.10–7.04), and a significant epistatic interaction was observed, the combined carriers of PECAM1-G and P-selectin-C alleles having an OR=16.25 (95% CI 1.44–183.10), in comparison with PECAM1-C and P-selectin-A double homozygotes. The above associations were strongest for the youngest subgroup of patients.

CONCLUSION: Our results indicate that PECAM1-C373G (Leu125Val) and P-selectin-A37674C (Thr715Pro) polymorphisms may be associated with IVF implantation failure.
Keywords:  implantation failure, IVF, in vitro fertilization, PECAM1, P-selectin, polymorphisms
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