May 28th, 2017

Next
A full text version of this article is available.
To access article obtain online access here or login
 
Title:
Analysis of Related Causes for No Embryos Transferred and Corresponding Coping Measures in Assisted Reproductive Technology
Authors:  Sen-lin Shi, Ph.D., Zhao-feng Peng, Ph.D., Gui-dong Yao, Ph.D., Hai-xia Jin, Ph.D., Wen-yan Song, Ph.D., Hong-yi Yang, M.D., and Ying-pu Sun, Ph.D.
  OBJECTIVE: To analyze the related causes for no embryos transferred in assisted reproductive technology (ART) in order to provide corresponding coping measures for infertile couples.

STUDY DESIGN: The data of 607 couples who underwent ART and had no embryos transferred in our reproductive center between January 2010 and January 2014 were retrospectively analyzed.

RESULTS: The cycles of no embryos transferred accounted for 3.99% (607/15,224) of total cycles. Of those, complete fertilization failure, oocyte retrieval failure, and complete abnormal fertilization accounted for 28.3% (172/607), 25.7% (156/607) and 22.24% (135/607), respectively. The incidence of complete abnormal fertilization was higher in IVF than in ICSI (p<0.05). In both IVF and ICSI cycles, the incidences of no embryos transferred were higher in the patients retrieving ≤3 oocytes than in the patients retrieving >3 oocytes (p<0.05). In IVF cycles the incidences of no embryos transferred were higher in the patients with primary infertility than in those with secondary infertility (p<0.05).

CONCLUSION: The main causes of no embryos transferred are complete fertilization failure, oocyte retrieval failure, and complete abnormal fertilization. Retrieving adequate number of mature oocytes is the key to success of ART. Patients who experienced complete abnormal fertilization in IVF or the patients with primary infertility who experienced complete fertilization failure or normal fertilization without cleavage should receive ICSI in the next treatment.
Keywords:  assisted reproductive techniques, embryo transfer, fertilization failure, in vitro fertilization, infertility, intracytoplasmic sperm injections, normal fertilization without cleavage, oocyte retrieval
   
   
  Acrobat Reader 7.0 is recommended to properly view and print the article.
Reader can be downloaded from