April 5th, 2020

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Impact of Extended Torsion on Ovarian Reserve: Experimental Torsion-Detorsion Model in Rabbit
Authors:  Bilge Cetinkaya Demir, M.D., Mehmet Aral Atalay, M.D., Fatma Oz Atalay, M.D., Emine Emsal Durusoy, M.D., Guven Ozkaya, Ph.D., Arzu Yilmaztepe Oral, M.D., and Kemal Ozerkan, M.D., Ph.D.
  OBJECTIVE: To evaluate the effect of duration of torsion on ovarian reserve.

STUDY DESIGN: Twenty-two female New Zealand rabbits were divided into a sham and 2 study groups. The torsion/detorsion (T/DT) groups had left adnexal torsion for either 3 or 6 hours followed by detorsion. Ovaries were evaluated histologically for follicular damage, and preoperative, predetorsion, and postdetorsion blood samples were drawn from each rabbit to measure anti-Müllerian hormone (AMH) levels.

RESULTS: Mean primary, small antral, and antral follicle counts were lower in the T/DT groups as compared to the sham group. Primordial, small antral, and antral follicle counts were not different between the 3-hour T/DT and 6-hour T/DT groups. When compared with contralateral ovary, the 6-hour T/DT group had significantly lower follicle count. The 6-hour T/DT group had higher percent change in both predetorsion and postdetorsion AMH levels as compared to the 3-hour T/DT group.

CONCLUSION: Although extended time of torsion has negative impact on ovarian reserve, the ovary keeps its viability with functioning follicles after detorsion.
Keywords:  anti-mullerian hormone; infertility, female; ovarian torsion; ovarian reserve; ovary; torsion abnormality
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