June 16th, 2019

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Title:
Blood Contaminated Amniotic Fluid and the Lamellar Body Count Fetal Lung Maturity Test
Authors:  Kevin C. Visconti, M.D., Craig V. Towers, M.D., Mark D. Hennessy, M.D., Bobby C. Howard, M.D., Stephanie Porter, W.H.N.P., and Beth Weitz, W.H.N.P.
  OBJECTIVE: To determine if maternal blood contamination falsely elevates the lamellar body count fetal lung maturity test.

STUDY DESIGN: Fifty mothers undergoing amniocentesis for fetal lung maturity consented to participation in the study. For each participant a blood-contaminated sample using the patient’s own blood was run in tandem with the noncontaminated sample used for clinical practice.

RESULTS: Of the 50 study patient samples the lamellar body count decreased by ≥3,000/μL in 33 (66%) and remained unchanged in 16 (32%). In only 1 case did the value increase—the actual result of 37,000/μL increased to 44,000/μL, both of which exceeded the mature level in our institution.

CONCLUSION: Maternal blood contamination of amniotic fluid does not falsely increase the lamellar body count in 98% of cases. The result was falsely lowered in 2 out of 3 cases. Therefore, a mature lamellar body count test result in a blood-contaminated sample is reliable.
Keywords:  amniocentesis, fetal lung maturity testing, lamellar body count, neonatal respiratory distress syndrome
   
   
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