April 8th, 2020

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Complete Hydatidiform Mole and Live Fetus in a Singleton Pregnancy with Confined Placental Mosaicism and Fetomaternal Hemorrhage: A Case Report
Authors:  Laxmi V. Baxi, M.D., Mahesh Mansukhani, M.D., Harshwardhan M. Thaker, M.D., and Elvira Parravicini, M.D.
BACKGROUND: Coexistence of complete mole and a live fetus is uncommon (1:22,000–100,000), more so with euploidy.

CASE: We present a case of a molar pregnancy with a euploid fetus who had close fetal evaluation for second trimester bleeding. The patient presented at 29 weeks’ gestation with decreased fetal movements, a result of fetomaternal hemorrhage. She underwent emergency cesarean section and delivered a live infant. By close follow-up and a multidisciplinary approach, the appropriate diagnosis and a favorable outcome were achieved. Both mother and the child at 5 years of age are doing well.

CONCLUSION: Detailed anatomic and molecular studies demonstrated a complete mole resulting from confined placental mosaicism, with molar tissue showing a single paternal allele at 8/8 informative loci, all shared with the fetus, thus this coexistent molar pregnancy was not that of a separate conceptus.
Keywords:  confined placental mosaicism, fetomaternal hemorrhage, hydatidiform mole, molar pregnancy, molar pregnancy with coexisting live newborn
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