April 26th, 2018

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Serum Beta Human Chorionic Gonadotropin Levels on Day 12 After in Vitro Fertilization in Predicting Final Type of Clinical Pregnancy
Authors:  Gengxiang Wu, M.D., Jing Yang, Ph.D., Wangming Xu, Ph.D., Tailang Yin, Ph.D., Yujie Zou, M.D., and Yaqin Wang, M.D.
  OBJECTIVE: To optimize the cutoff level for serum beta human chorionic gonadotropin (b-hCG) determination on day 12 after embryo transfer (ET).

STUDY DESIGN: This was a retrospective data analysis.

RESULTS: b-hCG values on day 12 after ET of 1,057 clinical pregnancies undergoing in vitro fertilization were analyzed. Receiver operating characteristic curves and optimal cutoff values to discriminate between singleton and multiple pregnancies, intrauterine pregnancy and ectopic pregnancy, and live-birth pregnancy and miscarriage were calculated separately. Cutoff values were found at 239 IU/L for multiple pregnancies (sensitivity 69.0%, specificity 74.5%, positive predictive value [PPV] 48.4%, negative predictive value [NPV] 86.1%), 91 IU/L for ectopic pregnancy (sensitivity 82.7%, specificity 71.1%, PPV 15.5%, NPV 98.5%), and 143 IU/L for miscarriage (sensitivity 72.3%, specificity 63.0%, PPV 33.1%, NPV 90.0%), respectively.

CONCLUSION: b-hCG cutoff values on day 12 after ET determined by a ROC curve analysis are useful to predict the final type of clinical pregnancy.
Keywords:  assisted reproductive technologies, b-hCG, ectopic pregnancy, embryo transfer, in vitro fertilization, miscarriage, multiple pregnancy
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