September 18th, 2014

Next
A full text version of this article is available.
To access article obtain online access here or login
 
Title:
Value of Amniotic Fluid IL-8 and Annexin A2 in Prediction of Preterm Delivery in Preterm Labor and Preterm Premature Rupture of Membranes
Authors:  Xiaohui Jia, B.Sc. (Clinical Medicine)
  OBJECTIVE: To investigate the clinical significance and value in the prediction of preterm delivery of combined amniotic fluid IL-8 and Annexin A2 levels in preterm premature rupture of membranes (PPROM) and preterm labor (PTL).

STUDY DESIGN: Sixty pregnant women at <32 gestational weeks who developed PTL were divided into a PPROM group and a non-PPROM group. Ten normal pregnant women served as a control group. IL-8 and Annexin A2 levels were measured in amniotic fluid samples from each patient.

RESULTS: Amniotic fluid IL-8 and Annexin-A2 levels in PTL (PPROM and non-PPROM groups) were significantly higher than those of the controls (p<0.05). The PPROM group displayed higher amniotic fluid Annexin-A2 levels than did the non-PPROM group, with a statistically significant difference (p<0.05). The PPROM group showed higher amniotic fluid IL-8 levels than did the non-PPROM group; however, this was statistically insignificant (p=0.56). Combined detection of amniotic fluid IL-8 and Annexin-A2 in the prediction of preterm delivery within 2 weeks of measurement showed sensitivity of 81.25%, specificity of 88.89% and PPV of 92.86%.

CONCLUSION: Amniotic fluid IL-8 and Annexin-A2 levels are associated with the occurrence of PPROM and PTL. Combined detection of IL-8 and Annexin-A2 levels in identifying preterm delivery within 2 weeks in PTL and PPROM is of possible clinical and predictive value.
Keywords:  amniotic fluid, Annexin A2, interleukin-8, premature rupture of fetal membranes, preterm labor, preterm premature rupture of fetal membranes, preterm premature rupture of membranes, preterm PROM (pregnancy), PROM (pregnancy)
   
   
  Acrobat Reader 7.0 is recommended to properly view and print the article.
Reader can be downloaded from