May 28th, 2018

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Measurement of Serum and Peritoneal Levels of Amyloid Protein A and Their Importance in the Diagnosis of Pelvic Endometriosis
Authors:  Dani Ejzenberg, M.D., Ph.D., Sérgio Podgaec, M.D., Ph.D., João Antônio Dias, Jr., M.D., Ph.D., Ricardo Manoel de Oliveira, M.D., Ph.D., Edmund Chada Baracat, M.D., Ph.D., and Maurício Simões Abrão, M.D., Ph.D.
  OBJECTIVE: To evaluate serum and peritoneal concentrations of amyloid protein A in women with endometriosis and to compare them with those of women without endometriosis.

STUDY DESIGN: A prospective study evaluated 76 women suspected of having pelvic endometriosis. Fifty-seven women (group A) were confirmed by videolaparoscopy and had their serum and peritoneal amyloid A concentrations measured by ELISA. The average levels from group A were compared to those obtained in group B. Group B was composed of 13 women without endometriosis, submitted to elective laparoscopy for tubal

RESULTS: Peritoneal amyloid A concentrations in group A (310.3±97.8 ng/mL) were higher than those of group B (53.4±58.2 ng/mL); p=0.0. However, serum concentrations in groups A (14.01±32.3 ng/mL) and B (9.5±15.9 ng/mL) did not differ significantly; p=0.35.

CONCLUSION: The peritoneal amyloid A protein concentration in pelvic endometriosis was higher when compared to normal controls, corroborating the inflammatory nature of the disease. This finding suggests that the procedure of evaluating the peritoneal amyloid A concentration in endometriosis merits further investigation.
Keywords:  amyloid A protein, diagnosis, dysmenorrhea, dyspareunia, endometriosis, infertility, pelvic pain
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