June 18th, 2018

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Influence of FSHR Diplotypes on Ovarian Response to Standard Gonadotropin Stimulation for IVF/ICSI
Authors:  Leandros Lazaros, Ph.D., Elissavet Hatzi, Ph.D., Nectaria Xita, M.D., Ph.D., Atsushi Takenaka, M.D., Ph.D., Nikolaos Sofikitis, M.D., Ph.D., Konstantinos Zikopoulos, M.D., Ph.D., and Ioannis Georgiou, Ph.D.
  OBJECTIVE: To explore the association of FSHR 307 (T/A)/FSHR 680(N/S) diplotypes with ovarian response to follicle stimulating hormone (FSH) stimulation of women undergoing medically assisted reproduction (in vitro fertilization [IVF] or intracytoplasmic sperm injection [ICSI]).

STUDY DESIGN: The study population consisted of 304 women undergoing IVF/ ICSI and 300 women with at least 1 spontaneous pregnancy as controls. FSHR polymorphisms were genotyped. Controlled ovarian stimulation and IVF/ICSI were performed in the 304 couples. During oocyte retrieval the follicular size, the follicle and oocyte numbers were recorded. Serum FSH, luteinizing hormone and estradiol were determined at the third day of the menstrual cycle.

RESULTS: The FSHR 307(T/A)/FSHR 680(N/S) diplotype analysis revealed lower serum FSH levels, higher follicle and oocyte numbers, increased numbers of large follicles as well as decreased empty follicle numbers in Thr307Thr/Asn680Asn women as compared to Thr307 Ala/Asn680Ser and Ala307Ala/Ser680Ser women (p< 0.006, p<0.01, p<0.008, p<0.01, p<0.005, respectively).

CONCLUSION: FSHR diplotypes were significantly associated with ovarian response to gonadotropin stimulation. FSHR diplotype analysis could be informative for ovarian stimulation outcome and the selection of the proper stimulation protocol, which would ensure a sufficient number of mature oocytes for IVF/ICSI.
Keywords:  FSH receptors, follicle-stimulating hormone receptors, infertility, oocytes, ovarian stimulation, single nucleotide polymorphism, SNPs
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