April 8th, 2020

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Granular Cell Tumor of the Uterine Cervix: A Case Report
Authors:  Fan Yang, M.D., Ph.D., Yan-Mei He, M.D., Xian-Ying Yao, M.D., and Kai-Xuan Yang, M.D.
BACKGROUND: Granular cell tumor (GCT) is a relatively rare and nearly always benign neoplasm that has been described in many sites and organs including the tongue, skin, subcutaneous tissue, breast, and vulva. However, it is rarely seen in the uterine cervix.

CASE: We report a case of granular cell tumor of the cervix in a 38-year-old woman. Upon microscopic examination the tumor was found to comprise large polygonal cells with an abundant eosinophilic granular cytoplasm and round to oval nuclei. Upon immunohistochemical staining the large cells showed S-100, neuron specific enolase, and CD68 positive in the cytoplasm. Clinical presentation of the patient, histopathological features of the lesion, and treatment approach are discussed.

CONCLUSION: GCTs of the cervix are extremely rare. To the best of our knowledge this report is the first Chinese case of cervical GCT in the English-language literature. GCTs should always be considered during the diagnosis process with large cell lesions of the cervix. Extensive surgical resection appears to be adequate for most GCTs. Because of the unpredictable clinical outcome of this tumor, strict and long-term follow-up are recommended.
Keywords:  granular cell myoblastoma, granular cell tumor, uterine cervix
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