June 16th, 2019

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Evaluation of the Effect of Vitamin E on Pelvic Pain Reduction in Women Suffering from Primary Dysmenorrhea
Authors:  Maryam Kashanian, M.D., Maziar Moradi Lakeh, M.D., Afsane Ghasemi, M.D., and Shahla Noori, M.D.
  OBJECTIVE: To evaluate the effect of vitamin E on the reduction of pelvic pain in women with primary dysmenorrhea and to compare its effect with placebo.

STUDY DESIGN: A double-blind randomized clinical trial was performed on 120 women suffering from primary dysmenorrhea. They were randomly assigned into 2 groups, and 94 women finished the study. In the study group (n=42) 400 IU/day of vitamin E was prescribed starting 2 days before the
beginning of menstruation and continuing for a total of 5 days, for 2 consecutive cycles. In the control group (n=52) a placebo was prescribed. Pain severity was evaluated using the Visual Analogue Scale for 1 month before the study and during the 2 months of study.

RESULTS: Pain severity during the first month of the study was 5.412.4 in the study group and 5.762.08 in the control group and 4.731.89 and 5.352.05 in the study and control groups, respectively, during the second month of the study. Pain severity during the first and second months of treatment with vitamin E and placebo was lower than the pain severity before treatment. The mean reduction of pain in the study group (2.72.1) was greater than that in the control group (1.82.4) during the second month of the study.

CONCLUSION: Both vitamin E and placebo may reduce the pelvic pain of dysmenorrhea, but vitamin E seems to cause a more significant reduction in pain. With regard to its safety, the study indicates it can be a simple and safe option for the treatment of dysmenorrhea.
Keywords:  dysmenorrhea, pain, painful menstruation, placebos, visual analogue pain scale, vitamin E
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