October 22nd, 2014

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Title:
Effect of Hysteroscopic Resection of Incomplete Uterine Septum on in Vitro Fertilization Outcome
Authors:  Cem Atabekog?lu, M.D., Elif Aylin Tas¸k?n, M.D., Bülent Berker, M.D., Batuhan Özmen, M.D., Suheyla I?s¸bacar, M.Sc., and Murat Sönmezer, M.D.
  OBJECTIVE: To investigate the effect of hysteroscopic correction of incomplete uterine septa on in vitro fertilization (IVF) outcome in patients presenting with primary infertility.

STUDY DESIGN: In this retrospective analysis 50 primary infertility patients with heterogeneous etiologies who underwent hysteroscopic resection of incomplete uterine septum before progressing to assisted reproductive technologies were enrolled in the study. A total of 100 primary infertility patients of similar age, infertility etiology and duration, and superovulation induction protocol but without uterine septum were selected as controls. The clinical pregnancy rate, miscarriage rate and implantation rate of the 2 groups were compared.

RESULTS: Clinical pregnancy rates per cycle were 51.56% and 53.91% in patient and control groups, respectively (p=0.803), and implantation rates per transferred embryo were 20.61% in the patient group and 21.25% in controls at the end of follow-up (p=0.950). Cumulative rates of first trimester pregnancy wastage were 12.12% and 4.83% in patient and control groups, respectively. Clinical pregnancy rate in the patient group at the first cycle and pregnancy rate per cycle at the end of the follow-up period were also statistically similar (p=0.556).

CONCLUSION: IVF outcomes of primary infertility patients with heterogeneous etiologies after hysteroscopic septoplasty were similar to those of similar patients without a uterine septum. Miscarriage rates remain slightly higher even after hysteroscopic septoplasty.
Keywords:  hysteroscopy, in vitro fertilization, infertility, uterine septum, uterus
   
   
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