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Title: |
Continuation of Pregnancy After Antenatal Corticosteroid Administration: Opportunity for Rescue? | |||||||||||||||||||
| Authors: | Christina Davidson, M.D., Manju Monga, M.D., Dayna Ellison, M.D., and Alex Vidaeff, M.D., M.P.H. | |||||||||||||||||||
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OBJECTIVE: To determine the duration of continuing pregnancy after antenatal corticosteroid (AC) administration and to evaluate the potential opportunity for rescue AC.
STUDY DESIGN: Retrospective analysis of women at 24–32 weeks’ gestation who received AC at one institution. RESULTS: Six hundred ninety-two women received AC. Two hundred forty-seven (35.7%) delivered at ?34 weeks’ gestation. Three hundred twenty-one (46.4%) delivered within 1 week of AC; 92 of those women (13.3%) delivered within 24 hours. Only 124 (17.9%) remained pregnant 1 week after AC and delivered at <34 weeks. The latter were compared to women delivering >1 week after AC but ?34 weeks. More likely to deliver at <34 weeks were those women who received AC for premature preterm rupture of membranes (OR 3.83, 95% CI 2.06–7.17), twins (OR 2.90, 95% CI 1.42–5.95) or before 28 weeks (OR 2.21, 95% CI 1.38–3.52). CONCLUSION: Rescue AC may apply to only 18% of cases, and we identified subsets of more likely candidates. (J Reprod Med 2010;55:14–18) |
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| Keywords: | corticosteroids, prenatal care, preterm birth, rescue dosing | |||||||||||||||||||
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