July 10th, 2020

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Progesterone for Preventing Premature Birth: Practice Patterns of Board-Certified Maternal-Fetal Medicine Specialists in the United States
Authors:  Amen Ness, M.D., Jason Baxter, M.D., Terry Hyslop, Ph.D., and Vincenzo Berghella, M.D.
  OBJECTIVE: To determine the current prescription of progesterone to prevent preterm birth (PTB) among board-certified maternal-fetal medicine (MFM) specialists in the United States.

STUDY DESIGN: A survey of the board-certified MFM specialists in the United States examining their prescription of and attitudes
regarding progesterone to prevent PTB 6 months following publication of a National Institute for Child Health and Human Development trial.

RESULTS: Of 1,264 questionnaires sent, 526 were returned (response rate, 42%). After exclusions, 522 surveys remained. One hundred ninety-eight (38%) respondents prescribed progesterone, and 324 (62%) did not. Most nonprescribers were awaiting more data and were more concerned than prescribers about long-term effects (p<0.0001). Twenty percent of prescribers prescribed progesterone for women with current signs or symptoms of preterm labor.

CONCLUSION: As a result of recent evidence, over one third of MFM specialists surveyed have begun prescribing progesterone to prevent PTB. Of these specialists, 20% are using it for indications other than a prior PTB. (J Reprod Med 2006;51:411-415)
Keywords:  premature birth, progesterone, clinical practice patterns
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