September 27th, 2020

A full text version of this article is available.
To access article obtain online access here or login
A Nutritional Supplement for Improving Fertility in Women: A Pilot Study
Authors:  Lynn M. Westphal, M.D., Mary Lake Polan, M.D., Ph.D., M.P.H., Aileen Sontag Trant, Ph.D., and Stephen B. Mooney, M.D.
  OBJECTIVE: To determine the impact of nutritional supplementation on optimization of reproductive health in women.

STUDY DESIGN: A double-blind, placebo-controlled pilot study was initiated to determine the effects of FertilityBlendTM (Daily Wellness Co., Sunnyvale, California), a proprietary nutritional supplement containing chasteberry and green tea extracts, L-
arginine, vitamins (including folate) and minerals. Changes in progesterone level, basal body temperature, menstrual cycle, pregnancy rate and side effects were monitored.

RESULTS: Thirty women aged 24-46 years who had tried unsuccessfully to conceive for 6-36 months completed the study. After 3 months, the supplement group (n=15) demonstrated a trend toward an increase in mean midluteal phase progesterone level (from 8.2 to 12.8 ng/mL, P=.08) and a significant increase in the average number of days in the cycle with basal temperatures >37?C during the luteal phase (6.8-9.7 days, P=.04). The placebo group (n=15) did not show any notable changes after treatment in any of the parameters studied. After 5 months, 5 of the 15 women in the supplement group were pregnant (33%), and none of the 15 women in the placebo group were (P<.01). No significant side effects were noted.

CONCLUSION: Nutritional supplementation may provide an attractive alternative or complement to conventional fertility therapy. (J Reprod Med 2004;49:289- 293)
Keywords:  infertility, female; nutritional support; pregnancy rate; FertilityBlendTM
  Acrobat Reader 7.0 is recommended to properly view and print the article.
Reader can be downloaded from