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Title: |
Increasing Clinical Pregnancy Rates After IVF/ET Can Immunosuppression Help? | |||||||||||||||||||
| Authors: | Gilbert L. Mottla, M.D., David B. Smotrich, M.D., Paul R. Gindoff, M.D., and Robert J. Stillman, M.D. | |||||||||||||||||||
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OBJECTIVE: To evaluate the safety and efficacy of immunosuppression as an adjunct to improving the success of in vitro fertilization/embryo transfer (IVF-ET).
STUDY DESIGN: A randomized, double-blind, placebo-controlled clinical trial. RESULTS: Seventy-five patients were randomized to receive either prednisone (39 patients, 51%) or placebo (36 patients, 49%). Patients in both groups had similar ages and numbers of preembryos transferred. CONCLUSION: Both the implantation and clinical pregnancy rates were higher in the prednisone group (16% vs. 11% and 43.5% vs. 32.3%, respectively). However, these differences did not achieve statistical significance. Evaluation of the ongoing pregnancy rate revealed little difference between the prednisone-treated patients (30.7%) and those receiving placebo (28.0%). There were no side effects reported by patients in either group. (J Reprod Med 1996;41:889-891) |
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| Keywords: | immunosuppression; fertilization in vitro; embryo transfer | |||||||||||||||||||
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