April 26th, 2018

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Endocrine Factors and Postpartum Depression: A Selected Review
Authors:  Sarah J. Breese McCoy, Ph.D., J. Martin Beal, D.O., and Gary H. Watson, Ph.D.
  This review examines proposed endocrine-based etiologies of postpartum depression (PPD) and how knowledge of these etiologies may affect future treatments. It is based on a review of papers shedding light on the etiology of PPD with special emphasis on research into endocrine-related depression. A picture of PPD is starting to emerge that suggests a variety of endocrine root causes as well as psychosocial risk factors. Hormones reviewed include progesterone, estradiol and estriol, cortisol, corticotropin-releasing hormone, prolactin, thyroid- stimulating hormone and triiodothyronine/thyroxine. Other substances examined include 3 antithyroid autoantibodies. Better understanding of the physiologic bases for depressive symptoms may lead to correction of the underlying pathology of PPD rather than treatment of symptoms. (J Reprod Med 2003;48:402-408)
Keywords:  postpartum depression, endocrine diseases, thyroid hormones
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