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Title: |
Regulation of Apoptosis in Squamous Cell Carcinoma of the Vulva | |||||||||||||||||||
| Authors: | Peer Hantschmann, M.D., and Rainer K¸rzl, M.D. | |||||||||||||||||||
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OBJECTIVE: To analyze the expression of Bcl-2, Bax and ICH-1-L in squamous cell cancer of the vulva.
STUDY DESIGN: Slides of 72 vulvar squamous cell carcinomas were stained immunohistologically for Bcl-2, Bax and ICH-1-L. They were analyzed for the percentage of positive tumor cells, staining intensity and pattern, and amount of Bcl-2-positive lymphocytes around the tumor. Results were analyzed for correlations with clinical and histologic characteristics. Disease-free and overall survival were evaluated by Kaplan-Meier curves with the log-rank test. RESULTS: Strong expression of Bcl-2 was present in 15% of tumors. Carcinomas with high Bcl-2 expression more frequently had lymph node metastasis (P=.03), without significant differences in other clinical or histologic parameters, disease-free and overall survival. Strong Bax expression was observed in 57%, without prognostic significance. Carcinomas showed high ICH-1-L expression in 35%. These tumors seemed to have longer disease-free survival, while overall survival was significantly longer (P=.02). A strong Bcl-2-positive inflammatory infiltrate was highly predictive of lymph node metastasis (P=.02) and disease-free survival (P=.03). CONCLUSION: In squamous cell carcinoma of the vulva, inhibition of apoptosis is associated with a more-aggressive phenotype, and a Bcl-2-positive inflammatory infiltrate is predictive of prognosis. A study with more patients should confirm the importance of apoptosis in vulvar carcinoma. (J Reprod Med 2000;45: 633-642) |
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| Keywords: | vulvar neoplasms, apoptosis, Bcl-2 genes | |||||||||||||||||||
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